胃左动脉丝裂霉素明胶微球栓塞的实验研究

Experimental study of left gastric arterial embolization with mitomycin C gelatin microspheres

目的 通过观察兔胃左动脉栓塞前后DSA改变 ,局部病理组织学改变 ,为临床应用提供科学理论依据。方法 经股动脉插管 ,用丝裂霉素明胶微球 (MMC -MS)行胃左动脉栓塞并做栓塞后即刻造影 ;分别于术手 6～ 8h、2 4h、72h及 1、2、4周行再造影复查并进行栓塞部位病理组织学观察。结果 镜下可见MMC -MS主要栓塞于粘膜、粘膜下层血管 ,引起水肿和局灶性细胞脱落、糜烂 ,随着MMC -MS降解 ,4周时局部损伤恢复正常 ;DSA显示 1周内栓塞血管无再通 ,2周有 1例 ,4周有 2例。结论 MMC -MS栓塞胃左动脉引起的组织损伤是可修复的 。

Objective To offer the theoretical evidence for clinical application,we observed the changes of angiographic appearances and local pathological changes before and after embolizing the left gastric artery with mitomycin C gelatin microspheres (MMC-MS).Methods Catheter was delivered into the left gastric arteries via femoral artery and then infused MMC-MS.The angiographic appearances and local pathological changes were observed immediately,and then with follow up of 6～8h,24h,72h,1w,2w and 4w. Results The minute arterioles of tunia mucosa and tela submucosa were mainly embolized inducing edema and focal necrosis.With the degradation of MMC-MS,the damage of gastric tissue was alleviated but turned normal after 4 weeks.The results of DSA showed that no recanalization of the embolized vessels occurred after one week of emboliatdion but revealed one recanalization after two weeks and two in four weeks.Conclusions The damage of tissue induced by embolizing the left gastric artery with MMC-MS can be recovered.The application of the MMC-MS is feasible.