慢性肺心病患者血浆α-颗粒膜蛋白及血管性假血友病因子的临床研究

A clinical study on plasma alpha granule membrane protein-140 and von willebrand factor levels in patients with chronic pulmonary heart disease

目的 对慢性阻塞性肺疾病所致肺心病患者体内血小板活化及血管内皮细胞受损程度进行对比分析。方法 采用双抗体夹心酶免疫吸附法分别测定肺心病急性发作期组 (5 0例 )、肺心病缓解期组 (38例 )和正常对照组 (37例)血浆血小板α -颗粒膜蛋白 (GMP - 140 )及血管性假血友病因子 (vWF)的含量。结果 在肺心病急性发作期血浆GMP - 140和vWF的含量均明显高于正常对照组 ,在缓解期血浆GMP - 140和vWF均比正常对照组升高。结论 慢性肺心病患者体内血小板被激活 ,血管内皮细胞受损 ,可能贯穿着肺心病的发生和发展的全过程 ,认识并纠正上述病理变化可能有助于肺心病疗效的提高。

Objective To study the activation of platelets in vivo and endothelial in patients with chronic pulmonary heart disease. Methods Plasma alpha granule membrane protein-140(GMP-140) and von willebrand factor (vWF) levels were determined by enzyme-linked immunosorbent assay in cor pulmonale exacerbation, cor pulmonale remission stage and in normal control. Results The levels of GMP-140 and vWF in cor pulmonale exacerbation and remission stage were significantly higher than that of normal control group. And the levels of plamsa GMP-140 and vWF in corpulmonals exacerbation were higher than that in remission stage.Conclusion Enhanced active action of platelets and injury in vascular endothlial juries may participate in the formation and progression of pulmonary heart disease.