m-AST/s-AST比值在急性心肌梗死诊疗中的应用

Clinical application of m-AST/s-AST in patients with acute myocardia infarction

目的 探讨谷草转氨酶线粒体同工酶 (m AST)与谷草转氨酶细胞浆内同工酶 (s AST)比值在急性心肌梗死(AMI)的早期诊断和AMI后再灌注检测的临床应用价值。方法 采用免疫抑制法检测AMI患者血清中m AST ,观察m ASTs AST比值与其他心肌酶的动态变化。结果 m AST与s AST比值AMI后 6h开始升高 ,然后下降 ,出现再灌注的患者血清中m ASTs AST下降速率 (0 2 8± 0 2 0 ) %明显高于常规治疗和没有出现再灌的患者 (0 11± 0 0 7) %。结论 m ASTs

Objective To explore the clinical application of ratio detection of aspartate aminotransferrase isoenzmyes mitochodrial AST(m AST)cytosolic aspart ate aminotransferrase isoenzmyes in early diagnosis and prediction of successful reperfusion in patients with acute myocardia infarction. Methods The activities of m AST were determined by immunosuppressive method.The ratio of m ASTs AST was compared with CK,CK MB,LDH,s AST for temporal changes. Results The decreased ratio of m ASTs AST in the cases who were successfully reperfused was(0 28±0 20)%that was significantly higher than that of conventionally treated and non reperfused cases(0 11±0 07)%. Conclusion m ASTs AST may be an excellent indicator for AMI in early stage and the decrease ratio of m ASTs AST would predict whether reperfution is successful or not at early stage of AMI.