E-CD的表达和胰腺癌浸润、转移的关系

Relation between E-CD expression and the invasion, metastasis of pancreatic cancer.

目的 探讨E -CD(E -Cadherin)在胰腺癌中表达及与胰腺癌浸润、转移的关系 ,评价E -CD在胰腺癌浸润转移中的作用。方法 采用SP免疫组化染色方法 ,检测 43例胰腺癌组织中E -CD的表达情况。结果 正常胰腺导管上皮细胞E -CD呈强阳性表达 ,6 0 .5 % (2 6 /43)的胰腺癌组织中E -CD呈异常表达 ,E -CD的异常表达与胰腺癌组织分化程度、浸润程度、淋巴结转移情况关系密切 (P <0 0 5 )。结论 E -CD异常表达与胰腺癌浸润、转移关系密切 ,检测E -CD表达有助于对胰腺癌浸润转移潜能的判断 。

Objective To elucidate the expression of E-CD in invasion and metastasis of pancreatic cancer and evaluate its value for the invasion and tumor metastatic potential. Methods The expression of E-CD was detected in 43 cases of pancreatic cancer. Method Streptavidin-peroxidase immunohistochemistry was used. Results The normal pancreatic tissue strongly expressed E-CD, whereas 60.5%(26/43)pancreatic cancers showed abnormal expression of E-CD .The siginificant correlation was observed between abnormal expression and differentiation, the depth of invasion and the lymph node metastasis( P <0.05). Conclusion The abnormal expression of E-CD has a close relation with the invasion and metastasis of pancreatic cancer. The determination of E-CD will help in predicting tumor invasion and metastatic potential. E-CD can serve as the biological marker of invasion and metastasis of pancreatic cancer.