微血管密度和血管内皮生长因子在涎腺腺样囊性癌中的表达

Clinico-pathological significance of microvessel density and vascular endothelial growth factor expression in adenoid cystic carcinoma of salivary glands

目的 研究微血管密度 (microvesseldensity ,MVD)和血管内皮生长因子 (vascularendothelialgrowthfactor,VEGF)在涎腺腺样囊性癌中的表达 ,探讨其与该肿瘤的临床病理关系。方法 采用SP免疫组织化学染色方法检测 5 5例涎腺腺样囊性癌中MVD和VEGF的表达 ,采用SPSS软件行统计分析。结果 VEGF在小涎腺腺样囊性癌中的高表达阳性 (强度 )率明显高于大涎腺 (P =0 0 398) ;随着肿瘤分期的增加 ,VEGF的高表达率明显增加 (P =0 0 175 ) ;而MVD与肿瘤部位、分期差异无显著性。MVD和VEGF的表达与该肿瘤的局部复发、远处转移、区域淋巴结转移、组织类型及生存率无显著的相关性。VEGF高表达组的平均MVD值明显高于低表达组的平均MVD值 (P =0 0 2 0 2 )。结论 在涎腺腺样囊性癌中 ,MVD和VEGF作为预后因素需要进一步的研究分析 ,二者的表达呈明显的正相关。

Objective To evaluate the clinical significance of microvessel density(MVD) and vascular endothelial growth factor(VEGF) expression in adenoid cystic carcinoma of salivary glands. Methods Immunohistochemical staining(SP) was used to quantify MVD and VEGF expression in specimens from 55 patients with adenoid cystic carcinoma of salivary glands. SPSS statistical software was used. Results High VEGF expression was correlated with tumor site and stage ( P= 0 039 8, P= 0 017 5), but not with local recurrence, distant metastasis, regional lymph node metastasis, histological classification and survival rate. A significant correlation was not noted between MVD and the above variables. The mean MVD in cases of high VEGF expression was significantly higher than those in cases of low VEGF expression ( P= 0 020 2). Conclusions In adenoid cystic carcinoma of salivary glands, MVD and VEGF may be served as a prognostic factor which needs further study, but there is a significant positive correlation between MVD and VEGF expression.