比较肝素和低分子量肝素对人单核细胞表面AGE受体的影响

THE EFFECT OF HEPARIN AND LOW MOLECULAR WEIGHT HEPARIN ON THE RECEPTOR OF AGE ON HUMAN MONOCYTE SURFACE

用放射性受体 配体结合分析法 ,观察肝素和低分子量肝素对正常人和慢性肾功能衰竭血液透析患者单核细胞表面晚期糖基化终产物 (AGE)受体的影响。结果表明 ,肝素对正常人和慢性肾功能衰竭血液透析患者单核细胞表面的AGE受体均有封闭作用 ,且这种封闭作用具有剂量依赖性 ;低分子量肝素对AGE受体无封闭作用。提示肝素可以干扰AGE的清除和降解 。

Radioactive ligand receptor binding assay was used to study the binding effect of heparin and low molecular weight heparin (LMWH) on the receptor of advanced glycation end products (AGE) on monocyte surface in normal individual and chronic renal failure (CRF) patients undergoing hemodialysis. The results showed that heparin caused a dose dependent inhibition of receptor binding to AGE, however LMWH did not have such inhibitory effects. The results suggest that heparin could interrupt AGE clearance and degradation, and LMWH had not these effects.