郑州市1992～1996年结核分支杆菌原发耐药性观察

Primary drug resistance of Mycobacterium tuberculosis in Zhengzhou(1992～1996)

目的 了解郑州市 1992～ 1996年结核分支杆菌原发耐药性。方法 采用绝对浓度法进行6种抗结核药物的耐受性测定。结果 总原发耐药率、耐RFP率分别由 1992年的 4 1.5%、19.5%降至 1996年的 2 9.6 %、11.1%。结论 1992～ 1996年郑州市结核分支杆菌原发耐药率和耐RFP率呈下降趋势。

Objective To illustrate the primary drug resistance of M.tuberculosis in ZhengZhou,during 1992～1996. Methods Absolute concentration method was used for the detection of drug sensitivity of 6 antituberculosis agents. Results The rate of total primary drug resistance and resistance to rifampin decreased from 41.5%,19.5% in 1992 to 29.6%,11.1% in 1996,respectively. Conclusion The primary drug resistance of M.tuberculosis and to rifampin decreased in Zhengzhou,1992～1996.