胸腔内灌注母牛分支杆菌疫苗治疗癌性胸液

Clinical observation of intrapleural injection of Mycobacterium vaccae vaccine for patients with malignant pleural effusion

目的 探索母牛分支杆菌疫苗在治疗癌性胸液中的作用。方法 肺癌并癌性胸液 4 0例 ,配对随机分组 ,治疗组胸腔内灌注母牛分支杆菌疫苗 10 0 0 μg 2～ 3次 ,对照组胸腔内灌注顺铂 4 0～6 0mg 2～ 3次 ,两组均同时给以全身化疗。结果 治疗组完全有效率 6 0 % (12 / 2 0 )明显高于对照组2 0 % (4/ 2 0 ) ,治疗组的有效率 90 % (18/ 2 0 )亦高于对照组的 55% (11/ 2 0 ) ,P <0 .0 5。结论 母牛分支杆菌疫苗可用于癌性胸液的局部治疗。

Objective To determine the effects of intrapleural injection of Mycobacterium vaccae vaccine for patients with lung cancer and pleural effusion. Methods 40 patients with lung cancer and malignant pleural effusion were divided into study group and control group at random pair.Mycobacterium vaccae vaccine 1000μg were injected into the pleural cavity once weekly for 2～3 weeks for the control group. Results 90%(18/20) of the study group achieved partial relief and 60%(12/20) had complete relief. Both of which were significant higher than those of the control group(P<0.05),while 55%(11/20) of the control group achieved partial relief and 20%(4/20) had complete relief,after 1yr follow-up,the relapse rat of pleural effusion of the study group was 5%(1/18),and the control group was 46%(5/11),P<0.05. Conclusion As adjunct to chemotherapy,Mycobacterium vaccae vaccine is helpful for patients with lung cancer and malignant pleural effusion.