绝经期妇女骨密度与细胞因子的变化

The Changes of Cytokines and Bone Mineral Density in Post-Menopausal Women

目的 观察绝经后不同年龄妇女骨密度与白细胞介素 1(IL 1)、白介素 6 (IL 6 )、肿瘤坏死因子 (TNF α)水平的变化。探讨骨质疏松症 (Osteoporosis ,OP)的发病及其机理。 方法 用双能X线吸收仪测定 2 0 7例绝经前后不同年龄妇女骨密度 ,采用定量夹心酶联免疫法测定血清IL 1、IL 6、TNF α水平。结果 骨量减少 2 8例 ,占 14.9% ,OP72例 ,占 38.5 % ,正常行经对照组 2 0例 ,骨量减少 1例 ,占 0 .5 % ,各年龄组与对照组差异显著 (P<0 .0 1)。结论 妇女绝经后 ,雌激素水平明显下降 ,雌激素对细胞因子的抑制降低 ,因而IL 1、IL 6、TNF α血清水平明显升高 ,增强了破骨细胞的活性和形成 ,使骨转换加快 ,OP发病率升高[1] 。

Objective To study the pathogenesis of osteoporosis. Methods By observing bone mineral density (BMD) and the levels of IL?1,IL?6,TNF?α of 207 women including 187 post menopausal and 20 normal menstrual women. BMD was measured by DEXA in all women, and serum IL?1, IL?6 and TNF?α levels were measured by quantitative sandwiched ELISA. Results Among 207 subjects, 28 wre osteopenia subjects, accounting for 14.9%, and 72 osteoporosis subjects, accounting for 38.5%, but osteopenia occurred in one of 20 normal menstrual women. Tiere were significant differences between post menopausal and normal menstrual women ( P <0.01). Conclusion In post menopausal women, the levels of estrogen is low, the restriction on the secretion of cytokines decreases, so the levels of IL?1, IL?6 and TNF?α increase, the activity and formation of osteoclasts are strengthened, bone remodeling is accelerated, and the morbidity of osteoporosis thus increases.