配对螺旋样纤维(PHF)-Tau与神经细胞的死亡

The Paired Helical Filament of tau and Neural Cell Death

神经纤维缠结 (neurofibrillarytangles ,NFT)是老年性痴呆病的重要病理特征 ,人类神经tau分子聚集形成的配对螺旋样纤维 (pairedhelicalfilaments ,PHF)是NFT的主要成分 .最近研究表明 ,PHF与神经细胞的坏死和程序化死亡密切相关 。

Neurofibrillary tangle (NFT), paired helical filament (PHF) as the major component, is an important pathological character of Alzheimer's disease. Further evidence suggests that PHF plays an important role in neural cell death, including necrotic and apoptotic death. Induction of reactive oxygen species (ROS) by PHF production may be an important mechanism of neural cell death.