角质细胞生长因子研究进展

Progress in Kerationcyte Growth Factor

角质细胞生长因子 (KGF)属于成纤维细胞生长因子家族 ,它通过与受体 (KGFR)的结合 ,特异性地刺激上皮细胞的增殖 .KGF基因表达受到正负调控作用 ,正负调控作用的平衡对于KGF正常发挥功能具有重要意义 .KGF具有多种生物学功能 :参与组织、器官的发育 ,具有损伤防治功能 。

Keratinocyte growth factor (KGF), a member of fibroblast growth factor ( FGF), exerts proliferative and differenting effects on a variety of epithelial cells via binding to a specific FGF receptor. KGF gene expression is subject to positive and negative regulation. A fine balance of the regulation is important for normal function of KGF. Results have suggested that KGF play important roles in several aspects: the development of tissues and organs; prevent wound and facilitate wound healing; involvement in tissues malignant transformation.