摘要
对RNA药靶的特点、研究策略和针对RNA药靶的小分子药物筛选方法 ,进行了综述 .RNA的三级结构作为分子相互作用的识别位点和结合位点对RNA的生物功能的实现具有重要决定作用 。
The strategic and tactical advantages, principle, screening methods, achievements of RNA as a small molecule drug target were reviewed. The process of RNA maturation, transport, intracellular localization and translation are rich in RNA recognition sites that provide good opportunities for drug binding. Both RNAs and proteins are potential drug-binding sites.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第4期486-489,共4页
Progress In Biochemistry and Biophysics