α-LTX毒素和细胞分泌过程

α-latrotoxin and cellular secretion

α－ｌａｔｒｏｔｏｘｉｎ（ａ－ＬＴＸ）是一种突触前毒素；在细胞膜上它有两种受体。细胞内分泌过程是神经突触传递的必要步骤之一；与细胞内游离钙离子浓度密切相关，ａ－ＬＴＸ可以钙依赖性和钙不依赖性两种方式来影响细胞的分泌过程，对于研究分泌的分子机制和钙不依赖分泌有重要作用。

α-latrotoxin(α-LTX) is a kind of pre-synaptic neurotoxin. Two kinds of α-latrotoxin receptor are founded on cell membrane. Secretion in a key step in the process of synatic neurotransmission, and is closely related to the intracellular Ca2+ concentration. α-LTX mediates the secretion process in a Ca2+ dependant and Ca2+-independant manner. It's very important for the research of molecular mechanism underlined Ca2+-independent secretion.