摘要
提出了测定顺铂注射液中顺铂含量的反相高效液相色谱法 ,其线性相关系数为0 994,精确度为 0 45% (n =8) ,顺铂的回收率为 99 7%。该法也能用于顺铂注射液中杂质反铂的测定 ,实现顺铂与水合物、三氯氨铂 (铂B)的分离。提出了用氯化钠溶液替代空白溶剂 (顺铂注射液所用的溶剂简称 )
A method of determining content of cisplatin in cisplatin injection has been studied by reversed-phase high performance liquid chromatography having linear relative coefficient 0 994 with the accuracy of 0 45%(n=8).The recovery rate of cisplatin was 99 7%.the transplatin in cisplatin injection could also be determined by the present method.The experimental results showed the possibility of blank solvent for making cisplatin injection replace by sodium chloride solution as contrast solvent.
出处
《贵金属》
CAS
CSCD
2001年第2期32-35,共4页
Precious Metals
关键词
顺铂注射液
高效液相色谱分析
抗癌药物
Cisplatin injection
High performance liquid chromatograph
Analysis
