活血、益气方药对心梗后心衰大鼠血流动力学影响的实验研究

Experimental Study on Effect of Method of Activating Blood、Nourishing Qi and Their Prescriptions on hemodynamics of Heart Failure Post Cardiac Infarction of Rats

目的 :观察活血、益气等不同治则中药早期、晚期分别给药对心衰模型大鼠心功能的影响。方法 :采用冠状动脉结扎的方法造成大鼠心梗后心衰的动物模型 ,分别应用活血、益气、气血注射液早期给药 4周及 8周、晚期给药 4周 ,以西药组 (卡托普利 )作为对照药物。应用阻抗法观察给药后大鼠心功能的变化。结果 :早期给药组中均以活血组疗效最好 ,给药 4周与假手术组无差异 ,给药 8周与其余同期各给药组比较P <0 0 1或P <0 0 5。晚期给药组中益气组改善明显 ,但同期各治疗组间无差异。结论 :活血法治疗心衰以及早期给药对逆转心衰的发生和恶化有更好的作用 ,推测其在改善心梗后左室重塑和细胞坏死。

Objective:To study the different effect of method of activating blood and nourishing qi and their prescriptions given early or later operation on cardiac function of congestive heart failure model rats. Methods:The congestive heart failure post cardiac infarction rats model subjected to left coronary occlusion were made and given Huoxue injection,Yiqi injection and Qixue injection early for 4 weeks and 8 weeks and later for 4 weeks after operation. The cardiac function after using drugs were observed by impedance methods. Results:The improvement of cardiac function of activating blood group was best in groups given drugs early (contrasted to shamed operation group in given early for 4 weeks, P >0 05;contrasted to oter treated groups in given early for 8 weeks, P <0 01 or P <0 05),while the nourishing qi group was best in groups given drugs later,but there isn't difference among four treated groups. Conclusion:The effect of activating blood group given drugs early for 8 weeks was best in different groups,and there maybe a variation from syndrome of blood stasis to syndrome of asthenia qi.