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HLA、HPV感染与宫颈癌相关性研究进展

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摘要 人类白细胞抗原 ( human leucocyte antigen,HL A)是人类主要组织相容性抗原系统。 90年代以来 ,先后发现多种 HLA等位基因和单体型与人乳头瘤病毒 ( human papillomavirus,HPV)感染、子宫颈上皮内瘤样病变 ( cervical intraepithelial neoplasia,CIN)和宫颈癌相关联。本文就近年来HL A与 HPV。
作者 饶智国 张积仁
机构地区 广州军区武汉总医院 广州第一军医大学附属珠江医院肿瘤中心
出处 《国外医学（妇幼保健分册）》 2001年第2期61-64,共4页 Foreign Medical Sciences (Section of Maternal and Child Health)
关键词 宫颈癌 HLA HPV CIN
分类号 R737.33 [医药卫生—肿瘤]
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参考文献15

  • 1Segawa T, Sasagawa T, Yamazaki H, et al. Fragile histidine triad transcription abnormalities and human papillomavirus E6-E7 mRNA expression in the development of cervical carcinoma[J]. Cancer, 1999,85(9) :2001-2010.
  • 2Cuzick J,Terry G ,Ho-L ,et al. Association between highrisk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women[J]. Br J Cancer, 2000,82(7):1348-1352.
  • 3Lai HC, Sun CA, Yu MH, et al. Favaroable clinical outcome of cervical cancers infected with human papilloma virus type 58 and releted types [J]. Int J Cancer,1999,84(6) :553-557.
  • 4Wank R, T homssen C. High risk of squamous cell sarcinoma of the cervix for women with HLA-DQw3[J]. Nature, 1991,352: 723-725.
  • 5Ferrera A;Olivo A;Alaez C,et al. HLA DQA1 and DQB1loci in Honduran women with cervical dysplasia and invasive cervical carcinima and their relationship to human papillomavirus infection [J]. Hum Biol, 1999, 71(3):367-379.
  • 6Odunsi K, Terry G, Bell J,et al. Susceptibility to human papillomavirus associatd cervical intra-epithlial neoplasia is determined by specific HLA DR-DQ alleles[J]. Int J Cancer, 1996,67: 595-602.
  • 7Neuman RJ,Huttner PC, Li L ,et al. Association between DQB1 and cervical cancer in patients with human papillomavirus and family controls [J]. Obstet-Gynecol,2000,95(1): 134-140.
  • 8Montoya L, Saiz I, Rey G, et al. Vela-F Cervical carcinoma: human papillomavirus infection and HLAassociated risk factors in the Spanish population [J].Eur-J-Immunogenet, 1998,25 (5): 329-337.
  • 9Allen M, Kalantari M, Ylitalo N, et al. HLA DQ-DR haplotype and susceptibility to cervical carcinoma:indications of increased risk for development of cervical carcinoma in individuals infected with HPV 18[J]. Tissue Antigens,1996,48(1) :32-37.
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国外医学（妇幼保健分册）
2001年 第2期

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