慢性肾小球疾病血清TNF-α、IL-1β、IGF-Ⅱ及LN的改变

Serum TNF-α、IL-1β、IGF-Ⅱ Changes in the Chronic Nephritis Caese

目的 :探讨细胞因子在慢性肾小球疾病中的作用。方法 :采用 RIA法对 10 0例慢性肾小球疾病血清肿瘤坏死因子 - α(TNF- α)、白介素 - 1β(IL- 1β)、胰岛素样生长因子 - (IGF- )及层粘蛋白 (LN)进行了检测 ;结果 :肾小球疾病血清 TNF- α、IL- 1β、IGF- 及 LN均明显增高 (均 P<0 .0 1) ,且随着肾功能损害加重 ,这些细胞因子增高更明显 (P<0 .0 1～ 0 .0 5)。结论 :TNF- α、IL- 1β、IGF- 及 LN在慢性肾小球疾病损害及肾功能进行性进展中起着重要作用。

Objective:To explore cytokine effects in chronic nephritis caes.Methods:100 chronic nephritis cases were studied by detecting their serum levels of TNF α、IL 1β、IGF Ⅱ and Ln with RIA.Results:The detected four factors were all higher than those in normal cases ( P <0.01) and the serum levels increased with the impaired of the chronic nephritis.Conclusions:The four cytokines played an important role in the progress of the chronic nephritis.