氟马西尼治疗急性苯二氮类药物中毒症状——昏迷的临床应用价值的研究

The therapeutic effectof flum azenil on acute benzodiazepine poisoning

目的 :探讨苯二氮艹卓 类受体拮抗剂氟马西尼抗昏迷治疗的临床应用价值。方法 :随机将 12 6例急性苯二氮艹卓 类药物 (BZDs)中毒患者分为氟马西尼治疗组和常规治疗组 ,每组均为 6 3例。疗效分析采用修改的Glasgow昏迷量表 (MGCS)和观察者对患者的机敏力 /镇静程度评判量表 (OAA/ S)。结果 :6 3例 BZDs中毒患者经氟马西尼治疗后 15、30、6 0和 180分钟 MGCS得分较治疗前分别增加 5 .3分、8.0分、9.4分和 8.3分 ,与常规治疗组比较 ,MGCS得分则分别增加 5 .2分、7.7分、8.7分和 6 .9分 ,差异均具有显著性 (P均 <0 .0 1)。以OAA / S比较 2组疗效 ,氟马西尼治疗后平均得分值增加 1.8分 ,与常规治疗组比较 ,亦具有显著性差异 (P<0 .0 1)。结论 :氟马西尼治疗急性 BZDs中毒确有明显的症状逆转作用 。

Objective:To study the therapeutic effect of flumazenil on acute benzodiazepine poisoning. Methods:One hundred and twenty six patients with unconsciousness due to acute benzodiazepine poisoning were random ly divided into two groups.In the flum azenil treatm ent group(n=6 3) patients were treated with flumazenil,and the controls(n=6 3) received conventional therapy.A Modified Glasgow Coma Scale(MGCS) and Observer's Assessment of Alertness/ Sedation Scale(OAA/ S) were used in assessment of the m ental status.Results:MGCS increased by 5 .3,8.0 ,9.4,8.3points at 15 ,30 ,6 0 and 180 m inutes after intravenous flumazenil treatment compared with baseline value (all P<0 .0 1) ,and by 5 .2 ,7.7,8.7,6 .9points compared with controls (all P <0 .0 1) .OAA / S in flumazenil treatment group increased by 1.8points com pared with control group (P<0 .0 1) .Conclusions:Flumazenil can m arkedly alleviate benzodiazepine induced unconsciousness without serious side effect.