银屑病患者血清中抗溶血性链球菌抗体的类别及其意义

Detection of antibodies for IgG, IgM and IgA classes against whole Streptococcus hemolyticus in sera from patients with psoriasis and their significance

目的 : 探讨银屑病患者血清中抗 β 溶血性链球菌抗体的类别及其意义。 方法 : 用ELISA法测定各型银屑病患者及正常对照血清中抗β 溶血性链球菌相应的抗体IgG、IgM、IgA。 结果 : 各型银屑病患者血清中存在不同水平的抗β 溶血性链球菌之相应的IgG、IgM、IgA类抗体 ;与正常对照相比 ,IgM类抗体各型银屑病均高于正常对照 ,并有统计学差异 (P <0 .0 5 ) ;银屑病各型之间的比较 ,点滴状和斑块状银屑病与其余型别不同 ,IgG类抗体占优势。结论 : 在各型银屑病中虽然抗 β 溶血性链球菌各类别抗体水平不同 ,但趋势一致 ,特别是IgM类抗体的检测提示此微生物在银屑病病因的可能一致性 ,其中以点滴状银屑病为一典型的代表。

Objective: To determine antibodies for IgG, IgM and IgA classes against whole Streptococcus hemolyticus (WSC) in sera from patients with psoriasis and to correlate the antibodies with their significance.Methods:Antibodies against WSC antigens were detected with ELISA in patients with psoriasis and normal controls. Results: The titers of the antibodies against WSC antigens were different in all types of psoriasis and the distribution of antibodies showed the pattern of PG>PV>PE>PA>PP. The level of IgM antibody was significantly different between all types of psoriasis and normal controls. There was a significant difference in the level of IgG antibody between PG and other types of psoriasis (PE, PA and PP). Conclusion : The results suggest that Streptococcus hemolyticus might play an important role in the pathogenesis of psoriasis, particularly for guttate psoriasis. [