异常孕产史夫妇的细胞遗传学分析

Cytogenetic analysis in couples with abnormal pregnancy-labor history.

目的 :分析染色体异常与异常孕产史的关系。方法 :检测 117对异常孕产史夫妇双方外周血淋巴细胞核型。结果 :异常孕产史夫妇中异常核型检出明显高于普通人群 ,总检出率为 6 .83% ,其中 <孕 3月流产 /停止发育 15 4例 ,异常 11例 ,异常检出率为 7.14% ,>孕 3月流产或死胎 36例 ,异常 1例 ,检出率 2 .78% ,生育先天异常儿 5 4例 ,异常 4例 ,检出率 7.41% ,不育不孕 8例 ,异常 2例 ,检出率 2 5 %。异常核型中男性 9例 ,女性 7例。结论 :异常孕产史不但与染色体畸变有关 ,与染色体多态性也有关联。对异常孕产史夫妇进行染色体检查是必要的 ,可以寻找原因 ,为优生优育提供依据。

Objective:To analyse the connection between abnormal cytogenetic and abnormal pregnancy-labor history.Method:To analyse the chromosome type of circular lymphocytes in couples with abnormal pregnancy-labor history.Result:Abnormal chromosome rate is 6.83% in couples with abnormal pregnancy-labor history,much higher than that of common herd.Abnormal chromosome rate in couples with fetuses lose in early pregnancy is 7.14%,in couples with fetuses lose in middle and late pregnancy is 2.78%,in couples laboredg enetic abnormal babies before is 7.14%,in sterility couples is 25%, Conclusion:Abnormal pregnancy-labor history not only relate to chromosome aberration,but also to chromosome polymorphism.It is necessary to analyse chromosome type in couples with abnormal pregancy-labor history.