188例慢性肝病乙、丙、丁、庚型肝炎病毒感染研究

The characteristics of hepatitis B, C, D and G virus infection in 188 patients with chronic hepatic disease

研究 18 8例慢性肝病乙、丙、丁、庚型肝炎病毒的感染特点。结果表明 :HBV感染率最高 ,HGV次之 ,HDV最低 ,尚有 8.5 %为非乙丙丁庚型慢肝 ;有六种重叠感染模式 ,以乙庚重叠感染模式最多见 ,单一模式重叠感染未随着肝病慢性化程度的增加而增加 (P >0 .0 5 ) ;HBV、HGV重叠感染组的抗 -HBe阳性率和HBeAg阳性率分别与单纯HBV感染组比较差异均有显著性 (P <0 .0 5 )。提示HBV感染是本地慢肝的主要病因 ,HGV感染率较高值得重视 ,尚存在原因未明的病毒性肝炎 ;单一模式重叠感染不一定导致病情的慢性化和重症化 ;

The characteristics of hepatitis B, C, D and G virus infection in 188 patients with chronic hepatic disease were retrospectively studied in this article. Results showed that the highest infection rate was HBV, the second was HGV, the lowest was HDV. There were 8.5% with chronic non-hepatitis B, C , D and G with six overlapping infection models. The most common overlapping infection model was Hepatitis B and G. The single model of overlapping infection didn't increase with the increase of the chronic degree (P>0.05). In HBV, HGV overlapping infection groups, the anti-HBe positive rate and the HBeAG positive rate differred significantly with that in the pure HBV infection group (P<0.05). This study indicated that HBV infection was the primary reason for native chronic hepatitis and the high HGV infection rate should be recognized. Also there remained viral hepatitis with unknown causes. The single model of overlapping infection will uncertainly affect the chronicity and severity of the disease. The HGV overlapping infection may inhibit the HBV replication index.