多药耐药相关蛋白基因在肺癌组织中表达的意义

Expression of Multidrug Resistance-Associated Protein in Lung Cancer

目的 :探讨多药耐药相关蛋白 (MRP)基因在肺癌组织中的表达以及与化疗结果的相关性。方法 :采用免疫组化的方法检测 52例肺癌组织MRP的表达。结果 :鳞癌和腺癌的MRP表达阳性率为6 5 6 3%、6 2 5% ,显著高于正常组织 (P <0 0 5)。SCLC则与正常组织差异无显著性 (P >0 0 5) ;无纵隔淋巴结肿大者高于肿大者 (P <0 0 5) ;中、高分化者高于低分化者 (P >0 0 5) ;对鳞癌和腺癌化疗结果MRP阳性组与阴性组差异无显著性 (P <0 0 5)。结论 :MRP基因表达是鳞癌和腺癌产生原发性耐药的机制之一 ,与SCLC耐药无明显相关性。

Objective To eoxplore the expression of multidrug resistance associated protein(MRP)gene in lung cancer.Methods Immunohistochemistry was used to detect the expression of MRP in 52 patients.Resnlts The positive expression rate were significantly higher in NSCLC than in SCLC and normal tissue ( P <0 05).MRP expression of moderate to high differentiation carcinoma was higher than that of low differentiation carcinoma ( P <0 05).The was not correlation between the expression of MRP and the results of chemtherapy in NSCLC.( P >0 05).Conclusion The expression of MRP is one of major causes of resistance to NSCLC.