直肠癌术后放疗加不同剂量卡莫氟综合治疗的临床研究

Dose Escalation Study of Carmofur in the Postoperative Chemoradiotherapy of Rectal Cancer

目的 :研究人体对联合应用卡莫氟 (化学名 :1-乙胺基甲酰 - 5氟 - 2 ,4 -嘧啶二酮 )和放射治疗的耐受性 ,观察毒副反应与药物剂量的关系。方法 :将 2 0 0 0年 3月～ 2 0 0 1年 1月间行术后放射治疗的 31例直肠癌患者根据口服卡莫氟的剂量分成 30 0mg/d(A组 ,2 2例 )、4 50mg/d(B组 ,4例 )和 6 0 0mg/d (C组 ,5例 ) 3组 ,每例患者均连续服药 5周以上。对 3组的毒副反应进行评价和比较。结果 :毒副作用主要表现为白细胞下降 :A组 :I度 9例 (9/ 2 2 ) ,Ⅱ度 7例 (7/ 2 2 ) ,Ⅲ度 1例 (1/ 2 2 ) ;B组 :Ⅱ度 4例 (4 / 4 ) ;C组 :Ⅰ度 4例 (4 / 5) ,Ⅱ度 1例 (1/ 5)。其他毒副作用同单纯放疗相似。结论 :放疗加卡莫氟联合治疗的耐受性较好。在同步化放疗方案中卡莫氟的推荐剂量为 6 0

Objective To study the optimal dose of carmofur in the postoperative chemoradiotherapy of rectal cancer.Methods Thirty one patients of rectal cancer received the postoperative chemoradiotherapy from Mar,2000 to Jan,2001 were divided into three groups:group A,300 mg/d;group B,450 mg/d;group C,600 mg/d.All patients used carmofur for at least 5 weeks.The toxicities of these groups were analysed.Results The main toxicity was decrease of leukocytes.The incidence of Grade I,Ⅱ and Ⅲ of leukocytopenia were 9/22,7/22 and 1/22 respectively for group A;were 0/4,4/4 and 0/4 respectively for group B;and were 4/5,1/5 and 0/5 respectively for group C.The other toxicities were the same as they were in radiotherapy alone.Conclusions It is considered that carmofur combined with radiotherapy is well tolerated.The recommended dose of carmofur is 600 mg/d in postoperative chemoradiotherapy.