细胞周期素D_1与乳腺癌

Cyclin D_1 and Breast Carcinoma

细胞周期中G1 S相的转换是肿瘤细胞增殖的必要条件 ,细胞周期素 (cyclin)D1则是G1期进展的限速控制因素 ,故cyclinD1的表达与乳腺癌的发生发展密切相关。同时 ,cyclinD1在乳腺癌中的表达有助于评价乳腺癌的分期和分级 ,有助于乳腺癌治疗方案的选择及预后的判断。

G 1 S transformtion in the cell cycle is an essential criteria for the proliferation of tumor cells,while,cyclin D 1 is a key factor in G 1 phase progression ,so the expression of cyclin D 1 is closely associated with the occurrence and development of the breast carcinoma.Furthermor,the expression of cyclin D 1 is helpful for evaluation the phase and grade of breast carcinoma,choosing treatment plan and predicting prognosis.