何塞停在晚期乳腺癌治疗中的应用

Herceptin(trastuzamab)in the Treatment of Advanced Breast Cancer

何塞停 (Herceptin)是一种人性化单克隆抗体 ,能特异性地作用于HER 2受体过度表达的乳腺癌细胞 ,限制原癌基因HER 2 /neu的过度表达 ,抑制肿瘤细胞生长 ,增强化疗药物疗效并减轻其毒副作用。临床上单独或联合用于转移性乳腺癌的治疗已显示出良好的应用前景 ,并且具有毒副作用小 ,使用安全的优点。

Herceptin is a humanized monoclonal antibody that appears to inhibit the breast cancer cell overexpressing HER 2/neu,inhibit the growth of cancer cell,inhance the tumoricidal effects of Cytotoxic drug and reduce its toxicity.When used as a single agent in women with metastatic breast cancer or combined with cytotoxic drugs,it always shows gratified response.In this artical,the physiochemical characteristics,machanism of action and therapeutic effects of Herceptin.The toxicity of hereptim is nuld and tolerable were reviewed.