糖尿病患者心功能减退及其机制探讨

Research of the impaired heart function and its mechanism in diabetes mellitus patients

目的 探讨糖尿病（ＤＭ）患者心功能减退的机制。方法 用超声方法测量６０例ＤＭ患者的心功能，并与其临床、生化指标进行相关性研究。结果ＤＭ病人的ＬＶＥＦ低于正常对照组，但尚处于正常范围。二尖瓣舒张期血流频谱的Ｅ／Ａ值、ＥＩ／ＡＩ值和Ｔａ／Ｔｄ值显著降低，并与年龄及血糖呈显著负相关。结论 ＤＭ病人存在不同程度的心脏舒张功能的减退。血糖的显著升高是舒张功能明显减退的主要危险因素。

Objective To investigate the impairment of heart function and its mechanism in Diabetes Melliuts. Methods By using Doppler echocardiography, the cardiac function, clinical and lab findings of 60 Diabetes Mellitus patients were collected and researched. The correlation among echo data and those clinical and lab findings was analysed. Results It was demonstrated that left ventricular ejection function (LVEF) in DM patients was decreased,but LVEF remained in the normal range. E/A,E1/A1 and Ta/Td of the transmitral Doppler velocity curve were decreased. These parameters were negatively correlated to age and blood glucose level. Conclusion Impaired left ventricular (LV) diastolic function was found in DM patients. The significant increase of blood glucose was the main risk factor for the aggravated impairment of LV relaxation.