同步检测183例血清9项HBV标志物结果分析

Analysis of Serum 9 HBV Marks in 183 HBV Infected Patients Detected Synchronously

探讨检测 9项乙肝病毒 ( HBV)标志物对判断 HBV复制及活动性的意义 ,以指导临床抗病毒治疗。选 1 83例 HBV感染者 ,同步检测其乙肝 5项以及 Pre-S2 、PHSA-R、HBs Ag-Ig M、HBV-DNA。HBV-DNA、Pre-S2 、PHSA-R、HBs Ag-Ig M在“大三阳”中检出率分别为 86.36%、96.97%、93.94 %、95.4 5% ;在“小三阳”中检出率分别为 1 5.79%、4 4.74 %、39.4 7%、4 8.68% ,HBe Ag及 HBs Ag阴性时仍能检出 HBV-DNA。HBV-DNA、Pre-S2 、PHSA-R、HBs Ag-Ig M与 HBe Ag都可作为 HBV复制指标。Pre-S2 、PHSA-R、HBs Ag-Ig M同属乙肝病毒表面蛋白 ,其复制能力及传染性与滴度呈正相关。 HBe Ag及 HBs

The purpose of this analysis is to investigate the significance of detecting serum 9 HBV marks on judging the replication and the activity of HBV, so as to direct the clinical treatment of anti-virus. 183 HBV infected patients were selected, and the five indexes of hepatitis B, Pre-S 2,PHSA-R, HBsAg-IgM and HBV-DNA, were detected synchronously. The occurrence of HBV-DNA, Pre-S 2,PHSA-R, HBsAg-IgM are 86.36%,96.97%,93.94%,95.45%repectively when HBeAg is positive, and they are 15.79%, 44.74%, 39.47%,48.68% respectively when both HBeAg and HBsAg are negative. So it was concluded that HBV-DNA, Pre-S 2, PHSA-R, HBsAg-IgM and HBeAg can all be regarded as replication indexes. Pre-S 2, PHSA-R and HBsAg-IgM are all surface albumen, the replication and infectivity are in positive proportion to their quantity. Virus can still be replicated when HBeAg and HBsAg are negative.