摘要
探讨检测 9项乙肝病毒 ( HBV)标志物对判断 HBV复制及活动性的意义 ,以指导临床抗病毒治疗。选 1 83例 HBV感染者 ,同步检测其乙肝 5项以及 Pre-S2 、PHSA-R、HBs Ag-Ig M、HBV-DNA。HBV-DNA、Pre-S2 、PHSA-R、HBs Ag-Ig M在“大三阳”中检出率分别为 86.36%、96.97%、93.94 %、95.4 5% ;在“小三阳”中检出率分别为 1 5.79%、4 4.74 %、39.4 7%、4 8.68% ,HBe Ag及 HBs Ag阴性时仍能检出 HBV-DNA。HBV-DNA、Pre-S2 、PHSA-R、HBs Ag-Ig M与 HBe Ag都可作为 HBV复制指标。Pre-S2 、PHSA-R、HBs Ag-Ig M同属乙肝病毒表面蛋白 ,其复制能力及传染性与滴度呈正相关。 HBe Ag及 HBs
The purpose of this analysis is to investigate the significance of detecting serum 9 HBV marks on judging the replication and the activity of HBV, so as to direct the clinical treatment of anti-virus. 183 HBV infected patients were selected, and the five indexes of hepatitis B, Pre-S 2,PHSA-R, HBsAg-IgM and HBV-DNA, were detected synchronously. The occurrence of HBV-DNA, Pre-S 2,PHSA-R, HBsAg-IgM are 86.36%,96.97%,93.94%,95.45%repectively when HBeAg is positive, and they are 15.79%, 44.74%, 39.47%,48.68% respectively when both HBeAg and HBsAg are negative. So it was concluded that HBV-DNA, Pre-S 2, PHSA-R, HBsAg-IgM and HBeAg can all be regarded as replication indexes. Pre-S 2, PHSA-R and HBsAg-IgM are all surface albumen, the replication and infectivity are in positive proportion to their quantity. Virus can still be replicated when HBeAg and HBsAg are negative.
出处
《标记免疫分析与临床》
CAS
2001年第2期69-71,共3页
Labeled Immunoassays and Clinical Medicine