剖宫产术预防性应用抗生素的探讨

Study on preventive use of antibiotics in cesarean section

目的 探讨选择性剖宫产术预防性应用抗生素的方法。方法 将 60例选择性剖宫产术随机分成两组 :A组 3 0例 ,术前一次性应用头孢唑啉 ;B组 3 0例 ,术后 3d常规应用头孢唑啉。观察手术前后生殖道菌群变化及术后感染情况。结果 两组术后最高体温及体温恢复正常所需时间、两组手术前后血白细胞平均计数、细菌培养比较 ,差异均无显著意义 (P >0 0 5 )。人均抗生素用量A组 2 g ,B组 12 g ,两组比较差异有显著意义 (P <0 0 5 )。结论 剖宫产术和抗生素会影响阴道菌群 。

Objective To study on the method for preventive use of antibiotics in selective cesarean section.Methods 60 cases of selective cesarean section patients were divided into two groups randomly:30 cases in group A in which cefazolin was applied one off before operation;30 cases in group B in which cefazolin was applied routinely after operation,the change of genital flora and the infectious situation after operation.Results After operation,the peak body temperature and the time for body temperature to come back to normal level in two groups had no significant difference(P>0.05).The mean WBC number before and after operation in two groups had no significant difference(P>0.05).The results of germiculture before and after operation as well as in two groups had no significant difference(P>0.05).The average dosages of antibiotics for individuals in group A and group B were 2 g and 12 g respectively,they had significant difference(P<0.05).Conclusion Cesarean section and antibiotics may influence the vaginal flora in the normal female genital tract.Antibiotics should be applied properly in cesarean section operation.It is better to use antibiotics one off before operation in selective cesarean section.