萘丁美酮和吲哚美辛分别与甲氨喋呤合用治疗类风湿关节炎的不良反应

Adverse drug reactions to the treatment of rheumatoid arthritis with combination of nabumetone and methotrexate and with indomethacin and methotrexate

目的 比较非甾体抗炎免疫药 (NSAIDs)与慢作用抗风湿病药 (SAARDs)合用治疗类风湿关节炎 (RA)的不良反应发生情况。方法 对萘丁美酮 (NAB) +甲氨喋呤 (MTX)和吲哚美辛 (IND) +MTX两组病人采用问卷方式进行调查 ,同时查阅病人的病历和各种化验单。资料采用Epiinfo软件进行统计分析。 结果 两组病人治疗后的不良反应出现率除恶心和纳差的差异有显著意义外 (P <0 0 5 ) ,其余的不良反应出现率之间的差异均无显著意义 (P >0 0 5 )。结论 在RA治疗上常采用的NSAIDs与SAARDs合并用药中 ,选择性COX 2抑制剂NAB合用MTX在胃肠道的不良反应方面少于IND合用MTX。

Objective To coucpare the adverse drug reactions to the treatment of patients withrheumatoid arthritis by combination of non steroidal anti inflammatory drugs(NSAIDs) and slow acting anti rheumatic drugs(SAARDs).Methods By questionnaires among the two groups taking nabumetone(NAB) plus methotrexate(MTX) and indomethacin(IND) plus methotrexate(MTX) respectively,meanwhile,consulting their medical records and their various lab test reports.All these data were figured out and analyzed by Epi info.Results After treatment,there was no obvious difference(P>0.05) except in the case of indigestion and nausea(P<0.05) anmong the two groups.Conclusion Of NSAIDs and SAARDs commonly used to treat RA,there is indication that COX 2 alternative inhibitor NAD combined with MTX is superior to IND combined with MTX in adverse drug reactions of the digestive system.