生长抑素联合奥美拉唑治疗非食管静脉曲张性大出血

Somatostatin combining with losec treatment nen-esophageal varicose massive hamorrhage of dligestive tract

目的 观察生长抑素联合奥美拉唑控制难治性非食道静脉曲张性消化道大出血的疗效。方法 3 0例难治性消化道出血病人给予生长抑素 (somatostatin ,施他宁 )剂量首次 2 5 0 μg静注 ,之后再以 60 0 0μg/ 2 4h静滴 ,同时加用奥美拉唑 40mg静脉注射 ,每 4h一次 ,两药共同使用 3～ 5d。 结果 显效 2 0例(66 6% ) ,平均用药后止血时间 18± 6h ;有效 6例 (2 0 % ) ,平均用药后止血时间为 48± 2 4h ,总有效率为86 6%。结论 生长抑素联合奥美拉唑控制难治性非静脉曲张性消化道大出血 ,止血率高 ,副作用小 。

Objective To observe the clinical hemostasis curative effect of somatostatin combining with losec in the treatment of intreactable non esophageal varicose massive hemorrhage of the digestive tract.Methods 30 hemorrhage patients were intravenously given 250 μg of stilamin as the initial dose and followed by 6 000 μg intravenous drip every 24 hours;Simultaneously,the patients were given an intravenous injection of 40 mg losec every four hours.The two drugs were used in this way for 3～5 d.Results 20(66.6%) showed significant effect,with the average hemostasis time of 18±6 hours;6 of 30 cases(20%) were effective,with an average hemostasis time of 48±24 hours.The total effective rate was 86.6%.Conclusion The somatostatin drug stilamin combining with losec shows the merit of high hemostasis rate and low side effects in the treatment of intractable non esophageal varicosis massive haemorrhage of digesive tract,and is worth popularization.