绝经后妇女脑梗死患者性激素变化与胰岛素抵抗的关系

Relationship between sex hormones and insulin resistance in postmenopausal women with cerebral infarction

目的：为探讨绝经后妇女脑梗死患者性激素水平变化及与胰岛素抵抗的关系。方法：对３３例绝经１年以上妇女脑梗死患者（Ａ组）与２１例绝经１年以上无脑梗死健康妇女（Ｂ组）的血清雌二醇（Ｅ２）、促卵泡刺激素（ＦＳＨ）、促黄体生成素（ＬＨ）、睾酮（Ｔ）、血浆葡萄糖（Ｇ）、血浆胰岛素（ＩＮＳ）及胰岛素敏感指数（ＩＳＩ）进行检测。结果：Ａ组Ｅ２水平较Ｂ组明显降低，ＦＳＨ、ＬＨ、Ｔ水平显著增高。相关分析发现，Ｅ２与ＩＳＮ是显著负相关，而Ｅ２与ＩＳＩ呈显著正相关；Ｔ与ＩＮＳ呈显著正相关，与ＩＳＩ是显著负相关。结论：绝经后妇女脑梗死患者存在严重的性激素失调，且与胰岛素抵抗并存，可能参与绝经后妇女脑梗死发生和发展。

Objective: To study the changes of sex hormone in postmenopausal women with cerebral infarction and the relationship between sex hormones and insulin rsistance. Methods: 33 postmenopausal women with cerebral infarction (group A) and 21 postmenopaual women without cerebral infarction (group B) were selected to compare the serum levels of estradiol (E2), follicle stimulating hormone(FSH), luteinizing hormone (LH), testosterone (T), plasma glucose (G), insulin (INS) and insulin sensistivity index (ISI).Results: Analysis of variance revealed that serum levels of T, FSH, LH were significantly higher while E2 lower in group A than those in group B. Correlation analysis showed that serum E2 level was negatively correlated to INS as well as between T and ISI, and positively associated E2 and ISI, as well as between T and INS. Conclusion: The study indicates that significantly lower level of estradiol, hight level of testosterone and imbalance sex hormones and insulin resistance play an important role in the development of cerebral infarction.