单疱病毒性角膜炎大黄素治疗前后补体C_3及C反应蛋白的分析

Changes in serum complement C_3 and C-reactive protein after the treatment on herpes simplex keratitis with Rhubarb

目的 :分析中药大黄素对单疱病毒性角膜炎的治疗及免疫调节作用。方法 :对 6 2例 (86眼 )原发感染 /复发感染的单疱病毒性角膜炎患者分型、分组 ,常规用药外施加中药大黄素处理因素进行对照 ,在二周内观察疗效、时效及补体 C3值、 C反应蛋白值。结果 :原发基质型 HSK组的疗效、时效与复发基质型 HSK组的时效有统计学意义的改善 (团体 T检验 P<0 .0 5 ) ,原发基质型及复发浅层型 HSK组补体 C3值实验前后分别上升 1.6 5 g/ l和 1.41g/ l;C反应蛋白值实验前后分别上升 5 .74mg/ l和 3.39mg/ l (团体 T-检验 P<0 .0 5 )。结论 :中药大黄素对原发基质型、复发浅层型 HSK有改善治疗结果 ,调节补体 C3,促进免疫的作用。

Objective: To analyze the curative and immune opsonic effects of Rhubarb on herpes simplex keratitis (HSK).Methods: 62 patients with newly occurred or recurrent HSK were grouped and treated with Rhubarb, besides of routine treatments, as experimental groups. Complement C3 and C-reactive protein (CRP) were detected before and after 2 weeks of experiment. Results: There was an improvement of the curative effect on primary interstitial HSK (PIHSK). Both in the PIHSK and the recurrent superficial HSK (RSHSK) group, the curative courses became shorter; C3 levels were 1.65g/1 and 1.41g/1 higher than that before the treatments, respectively; and CRP levels were 5.74mg/l and 3.39mg/l higher (T-test, p < 0.05). Conclusions: Rhubarb could improve the curative effects on PIHSK and RSHSK, enhance the modulations of C 3 and the regulations of immuno-reaction.