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钠/碘同向转运体 被引量：2

The sodium/iodide symporter
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摘要 钠 /碘同向转运体是甲状腺滤泡细胞基底细胞膜上的糖蛋白 ,介导甲状腺对碘的主动运输。本文综述钠 /碘同向转运体在基因、蛋白质二级结构、电生理学特征、调控及组织分布等方面的进展 ,及其对甲状腺疾病和放射性碘治疗的意义。 The sodium/iodide symporter(NIS), an integral plasma membrane glycoprotein of the basolateral membrane of the thyroid gland follicular cells, mediates the active transport of iodide into thyroid cells. In this review, the main accomplishments of the study of NIS at molecular level were concisely described, including the NIS gene, the secondary structure and electrophysiological character of NIS protein, and their regulation and tissue distribution. The impacts of NIS on thyroid disease and radioactive iodide therapy were also evaluated.
作者 柳卫
机构地区 核医学国家重点实验室
出处 《国外医学（放射医学核医学分册）》 2001年第2期49-52,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 钠/碘同向转运体 放射性碘治疗 甲状腺 sodium/iodide symporter radioactive iodide therapy
分类号 R817 [医药卫生—影像医学与核医学]
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参考文献33

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同被引文献30

  • 1张恒,朱精强,唐颖,李志辉,魏涛.NIS蛋白表达对甲状腺癌诊断及^(131)I疗效预测的相关性研究[J].中国普外基础与临床杂志,2007,14(5):554-559. 被引量：5
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  • 5Dohan O, De la Vieja A, Paroder V, et al. The sodium/iodide Symporter(NIS) characterization, regulation, and medical sig- nificance[J]. Endocr Rev, 2003, 24(1) :48-77.
  • 6Postiglione MP, Parlato R, Rodriguez-Mallon A, et al. Role of the thyroid- stimulating hormone receptor signaling in devel- opment and differentiation of the thyroid gland[J]. Proc Natl Acad Sci USA, 2002, 99(24):15462-15467.
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引证文献2

二级引证文献3

国外医学（放射医学核医学分册）
2001年 第2期

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