基因转染诱导核素靶向治疗的实验研究

Inducement of radionuclides targeting therapy by gene transfection

应用基因转染技术 ,诱导肿瘤细胞表达某种表面抗原或受体 ,使肿瘤细胞能够选择性地摄取某一放射性核素或其标记物 ,以便能够应用放射性核素治疗恶性肿瘤。目前的研究主要包括 :癌胚抗原 (CEA)基因转染诱导放射免疫治疗 ,钠 /碘同向转运体 (NIS)基因转染诱导 1 3 1 I治疗以及去甲肾上腺素转运体 (NAT)基因转染诱导间碘苄胍(MIBG)治疗等。通过基因转染 ,可以使核素治疗恶性肿瘤的范围进一步扩大 ,为核素治疗开辟了一条崭新的途径。

This review presents an overview of gene transfection methods to genetically induce tumor cells to express enhanced levels of cell surface antigens and receptors to intake radiolabeled antibody and peptide targeting and thus increase their therapeutic effect in radiotherapy. The current research include inducement of radioimmunotherapy through CEA gene transfection, inducement of iodine 131 therapy by sodiumiodide symporter gene transfection and inducement of MIBG therapy by noradrenaline transporter gene transfection. These studies raise the prospect that gene therapy techniques could be used to enable the treatment of a wide range of tumors with radiopharmaceuticals of established clinical acceptability.