苍术、黄柏及二妙丸超细微粉的生物药剂学的研究Ⅰ.扫描电子显微镜技术对超细微粉的表征

Studies on biopharmacy of ultra-fine particles of Atractylodes lancea, Phellodendron chinense and a pill composed of the two drugs Ⅰ. Characterization by scanning electron microscopy

目的 为了表征苍术、黄柏及二妙丸的超细微粉 ,了解其理化特性。方法 采用扫描电子显微镜、生物显微鉴别、粒径、松密度及比表面积测定等方法对中药普通粉和超细微粉进行了表征。结果 超细微粉颗粒大小均匀 ,90 %小于 2 0 μm,比表面提高 6 0 %～ 190 % ,松密度约为 0 .42 g/ cm3,绝大多数细胞被破碎。结论 苍术、黄柏及二妙丸经超细微化后 ,粉末颗粒大小均匀 ,球性度及均质度明显改善 ;松密度及比表面显著提高 ,植物细胞破壁率高。

Object To characterize the ultra fine particles of Atractylodes lancea (Thunb ) DC., Phellodendron chinense Schneid and the ERMIAO PILL *, a compounded preparation of the above two drugs, for the purpose to observe a deeper view on their physico chemical properties Methods By comparing their particle size, porosity and specific surface area with light and scanning electron microscope Results The size of the ultra fine particles were more uniform in size, 90% of which were under 20 μm, their specific area were increased by 60% ～ 190% and bulk density were around 0 42 g/cm 3, and the great majority of the plant cells were broken as compared with the conventional coarse powder Conclusion Both A. lancea and P chinense together with their combined preparation became smaller in particle size, more uniformly distributed with increased specific surface area and broken cell wall