水杉总黄酮抗实验性心肌肥厚及抑制心室c-Fos蛋白表达的作用

Inhibitory effects of total flavones of Metasequoia glyptostroboides on experimental cardiac hypertrophy and expression of c-Fos protein in ventricle

目的 观察水杉总黄酮 (TFM)对容量超负荷大鼠心肌肥厚的作用及其对心室 c- Fos蛋白表达的影响。方法 采用腹腔动 -静脉造瘘建立大鼠容量超负荷模型 ,ig给予 TFM,免疫组化测定心室 c- Fos蛋白的相对含量。结果 TFM剂量依赖性地减轻大鼠心脏重量 ,抑制心室 RNA和蛋白质合成 ,并抑制心室 c- Fos蛋白表达。结论 TFM可预防容量超负荷大鼠心肌肥厚的形成 ,抑制心室 c- Fos蛋白表达可能是其分子机制之一。

Object To observe the effects of total flavones of Metasequoia glyptostroboides Hu et Cheng (TFM) on volume overload cardiac hypertrophy and the expression of c Fos protein in rat Methods Volume overload cardiac hypertrophy of rat was induced by aortocaval shunts The rats were given ig TFM (400, 40 and 4 mg/kg/d) c Fos protein in the ventricles were measured by immunocytochemical study Results TFM at the above dosage decreased heart weight and contents of RNA and protein in the myocardium, inhibited the expression of c Fos protein in the ventricles Conclusion TFM can prevent volume overload cardiac hypertrophy in rats The inhibitory effects on the expression of c Fos protein may be its mechanism in the molecular level