Study on relation among sICAM-1 level change in the patients withchronic viral hepatic disease,viral replicationand the clinical significance

目的 :探讨慢性肝病患者血清可溶性粘附分子 (s ICAM)水平与病毒复制及临床关系。方法 :采用 EL ISA法对慢性肝病患者血清 s ICAM、炎症相关性细胞因子白细胞介素 - 1(IL- 1)、白细胞介素 - 8(IL- 8)及肿瘤坏死因子 (TNFα)水平进行了平行测定。结果 :慢性肝病患者血清 s ICAM- 1、IL - 1、IL - 8及TNFα水平明显高于健康对照组 ;慢性乙型肝炎 HBV- DNA或 HBe Ag阳性患者明显高于 HBV- DNA或 HBe Ag阴性患者 ,且与血清总胆红素含量呈正相关。结论 :s ICAM- 1和炎症相关性细胞因子水平与慢性肝病患者病情及携带

Objective:To observe relation among sICAM-1 level in the sera of patients with chronic viral hepatic disease,viral replication and the clinical significance.Methods:The level changes of sICAM-1,IL-1,IL-8 and TNFα in the sera of patients with chronic hepatitis B(CH),chronic severe hepatitis B(CSH) and hepatocirrhosis (HC) were detected by ELISA.Results:The levels of sICAM-1,IL-1,IL-8 and TNFα in sera of the patients with chronic viral hepatic disease were significantly higher than those of healthy control group ( P <0 01).The bilirubin level in the sera of patients with chronic viral hepatic disease of different clinical types positively correlated with sICAM-1 and cytokine activities.The sICAM-1 level in the sera of HBV-DNA or HBeAg positive patients was significantly higher than those of negative patients ( P <0 05, P <0 01).Conclusion:The sICAM-1 level and activities of cytokine IL-1,IL-8 and TNFα as well as the bilirubin level in the sera of the patients can reflect the necrosis degree of hepatocytes,and the sICAM-1 level and activities of IL-1,IL-8 and TNFα were related to state of HBV carrier or the active degree of HBV in patients with hepatic disease.