血清真胰岛素、胰岛素原与冠心病关系初探

Relationships of concentrations of true insulin, proinsulin to coronary heart disease: a preliminary study

目的 探讨冠心病 (CHD)患者血清真胰岛素 (TI)、胰岛素原 (PI)水平 ,并分析这二者与其他CHD危险因子的关系。方法 对 30例确诊CHD患者和 30例正常人采用高度特异性的ELISA法分别检测空腹血清TI、PI和以RIA法检测空腹血清免疫活性胰岛素 (IRI)水平 ;同时检测这二组对象的空腹和餐后 2小时血糖、血脂以及血压水平。结果 CHD组IRI、TI、PI水平均高于对照组 (P <0 .0 5 ) ,而胰岛素敏感指数 (ISI)则低于对照组 (P <0 .0 5 )。CHD组中TI、PI与年龄、BMI、血糖和血脂均有独立的相关关系。结论 CHD患者有高胰岛素血症和胰岛素抵抗状态 ,TI、PI分别与血糖。

Objective To determine serum true insulin (TI) and proinsulin (PI) levels in patients with coronary heart disease (CHD), and to explore the relationships of them to other cardiovascular risk factors. Methods Highly specific ELISA assays for TI and PI and RIA for immunoreactive insulin (IRI) were used. The fasting serum IRI, TI, PI levels in 30 nondiabetic patients with CHD and 30 healthy, age matched control subjects were investigated. And the fasting and 2h postprandial plasma glucose, serum lipids and blood pressure were also determined in each individuals. Results The levels of serum IRI, TI and PI were significantly higher in patients with CHD than those in controls (P<0.05), while the value of insulin sensitivity index (ISI) was lower in patients with CHD than in controls (P<0.05). There were significant independent correlations between TI, PI and age, BMI, plasma glucose, serum lipids. Conclusion Nondiabetic patients with CHD have hyperinsulinemia and insulin resistance and there is an independent association between proinsulin and dyslipidemia.