神经生长因子受体在先天性胆总管囊肿表达的意义

The implication of expression in congenital choledochal cyst

目的 :探讨神经生长因子受体 (NGFR)在先天性胆总管囊肿 (CCC)的分布情况及其意义。方法 :应用免疫组化方法对 18例CCC患儿及 9例对照组的胆总管进行检测。结果 :丰富的NGFR染色阳性神经纤维分布于正常胆总管外膜下 ,神经节细胞表现为NGFR染色强阳性 ,先天性胆总管囊肿狭窄段及上段NGFR染色阳性纤维明显减少。结论 :NGFR在先天性胆总管囊肿的异常分布可能与CCC的发病机理有关。

Objective: To evaluate the distribution of nerve growth factor recptor( NGFR) in Congenital choledochal cyst(CCC) and its clinical implication .Methods:Specimens from 18 children with CCC and normal choledochal specimens from 9 controls were immuno-stained with NGFR antibody.Results: Extensive NGFR staining was found in the nerve fibres of normal choledochal , strong staining of ganglion cells were observed on the normal specimens. There are very littel immunoreactive fibre in the CCC.Conclusions: The abnormal distribution of NGFR in the aganglionic choledochal suggests involvement of NGFR in the CCC.