α_(1A)受体阻滞药治疗慢性前列腺炎疗效观察

Clinical survey of treatment of chronic prostatitis with α_(1A) adrenoceptor blocker

目的：观察α１Ａ受体阻滞药合用抗生素治疗慢性前列腺炎的疗效，探讨α１Ａ受体阻滞药在缓解慢性前列腺炎综合征中的作用与机制。方法：将１７８例慢性前列腺炎患者随机分为两组，实验组口服α１Ａ受体阻滞药（盐酸坦格新）及氧氟沙星，对照组仅口服氧氟沙星．治疗６周，观察治疗前后尿动力学指标、前列腺液常规及前列腺炎症状评分的变化。结果：合用α１Ａ 受体阻滞药治疗慢性前列腺炎较单用抗生素更为有效。结论；α１Ａ受体阻滞药可降低后尿道压力，缓解尿液前列腺反流．改善慢性前列腺炎患者的症状。

Purpose: To investigate the efficiency of a1A adrenoceptor blocker in treatment of chronic prostatitis. Methods: 178 patients with chronic prostatitis received either α1A adrenoceptor blocker(tamsulosin) combined with ofloxasin or the latter alone for 6 weeks. Symptoms scores, urodynamic indexes and prostatic secretion examination were recorded before and after therapy. Result: There are more significant therapeutic effects of tamsulosin combined with ofloxasin than that of ofloxasin alone in the treatment of chronic prostatitis. Conclusion:α1A adrenoceptor blocker can decrease the intraurethral pressure, prevent urethroprostatic reflux, improve urinary symptoms of patients with chronic prostatitis.