含氟羟基磷灰石的合成与性能研究

Wet Synthesis and Characterization of Fluoride-substituted Hydroxyapatite

采用湿法合成羟基磷灰石和两种不同氟含量的含氟羟基磷灰石粉 ,在 30 0、6 0 0、90 0℃热处理。并将90 0℃热处理的两种含氟羟基磷灰石及羟基磷灰石的压片在模拟体液内浸泡 ,采用扫描电镜及溶液离子浓度测定法观察其体外生物活性。红外光谱分析显示通过热处理可去除含氟羟基磷灰石及羟基磷灰石内的杂质成分 ,获得标准比的羟基磷灰石。X线衍射分析显示含氟羟基磷灰石的热稳定性差 ,90 0℃出现很弱的 β- Ca3(PO4) 2 衍射峰。

Hydroxyapatite and fluoride-substituted hydroxyapatite powders are synthesized by wet method, compacted into pallets and subjected to heat treatment at 300, 600, 900°C respectively. Analysis of the fluoride-substituted hydroxyapatites and HA by FTIR spectroscopy indicated that with the increasing of sintering temperatures, the phase-pure fluoride-substituted hydroxyapatite and stoichiometric hydroxyapatite could be got. According to the X-ray diffraction analysis, the fluoride-substituted hydroxyapatite is less stable for decomposing into β-Ca3 (PO4)2 at the temperature of 900°C. The in vitro bioactivity of the fluoride-substituted hydroxyapatites and hydroxyapatite heat treated at 900°C was assessed by immersion testing in simulated body fluid (SBF). Both scanning electron microscopy (SEM) analysis and ionic solution changes (Ca2+) demonstrated that the low fluoride content apatite could induce a surface bonelike apatite layer formation.