脑深部电刺激参数调整和随访治疗帕金森病震颤及强直的疗效研究

The effect of deep brain stimulation and follow－up treatment on tremor and spasm of peakinson's disease

目的观察脑深部电刺激(DBS)治疗帕金森病(PD)术后症状改善，并应用电流脉冲发生器(IPG)进行参数调整以达最佳临床效果。方法2例PD患者进行了手术，采用立体定向系统，以微电极引导将刺激电极植入相应靶点，例1选择丘脑腹中间核(Vim)，例2选择丘脑底核(STN)为靶点。结果术后各种参数相对稳定，在反复启动和关闭IGP前后，差别明显。结论DBS治疗PD安全有效，副作用可逆，，IGP参数调整和随访是DBS手术是否成功的重要部分。

Objective To observe effects of deep brain stimulation(DBS) on Parkinson's disease(PD) and adjust implanting pulse generator(IGP) to get the best control for PD symptoms.Method Two PD patients underwent microelectrode－guide stereotaxic DBS surgery, left Vim (ventral intermediate thalamic nucleus) as target,case 2 target in patients, were bilateral STN(subthalamic nucleus) as target in patient 2.Result After operation,all parameters were stable.With IPG on and off,the clinical symptoms developed very differently.Conclussion DBS is a safe and effective new method for PD,the side－effects are reversible,the adjustment of IPG parameters and follow－up study are the important parts of the success of DBS.