脑梗死患者恢复期脑组织血浆肿瘤坏死因子-α、白介素-1β含量变化

Dynamic observation of splasma tumor necrosis factor－αand Interleukin－1βin patients with cerebral infarction

目的观察急性脑梗死患者血浆肿瘤坏死因子－α(TNF－α)、白介素－1β(IL－1β)含量变化。方法采用双抗体夹心（ELISA）法测量44例急性脑梗死患者急性期、恢复期血浆TNF－α、IL－1β含量，并与40例正常对照组相比较。结果急性期脑梗死患者血浆TNF－α、IL－1β含量较恢复期及对照组均显著增高，P< 0.01。恢复期TNF－α、IL－1β含量虽明显下降，但较对照组为高，P< 0.01。二者含量变化的关系与病情严重程度相一致。结论急性脑梗死患者存在神经－炎症/免疫－内分泌功能紊乱，两者可能参与了脑梗死急性期的炎症反应及再灌注损伤。

Objective To observe the change of plasma levels of tumor necrosis factor－α(TNF－α) and interleukin－1β(IL－1β) in patients with acute cerebral infarction(ACI) and its clinical significance.Method The plasma TNF－αand IL－1βconcentration of 44 patients with CI and 40 control subjects were measurd by ELISA method.Result The plasma TNF－αand IL－1βconcentration significantly higher in acute stage of CI patients than that of control group and recovery stage ,P< 0.01. The plasma TNF－αand IL－1βlevel was decreased in the recovery stage . However,it was still significantly higher than that of contral group(P< 0.01). Among the patients in the modarate and serious cases ,the TNF－αand IL－1βlevel were significantly higher than in slight cases (P< 0.01).Conclusion There is disturbance of neuro－inflammatory/immune－endocrine function in cerebral infarction, TNF－αand IL－1βpossibly participate the inflammatory reaction in early cerebral infarction and the damage after reperfusion.