绞股蓝、乌龙茶抗肿瘤实验研究

An Experimental Study of the Anti-tumour Effect of Jiaogulan and Oolong Tea

侧重探讨药物在体内环境中产生效应的过程 .以地产绞股蓝和当地习惯饮用的乌龙茶直接给动物饮用 ,观察它们的抗肿瘤作用 .结果 :饮用 15 0 mg/只 /日绞股蓝、30 mg/只 /日乌龙茶的荷瘤鼠生存期较饮水组明显延长 (P<0 .0 5 ) ,开始发生死亡的时间推迟 7～ 8d,并对瘤体早、中期增长速度有明显抑制作用 (P<0 .0 5～ 0 .0 0 1) ,且外观生存质量也好于饮水组 .但绞股蓝在 30 mg/只 /日浓度时却无上述作用 .另外 ,乌龙茶体外对于多种肿瘤细胞株增殖均有较强抑制作用 ,以 2 0 0 μg/ m L浓度作用最强 ,抑制率均 >86 .2 %

The present work attempts to discover the anti tumour effect of drinking Jiaogulan and Oolong tea in two groups of mice infected with tumour. The results showed that those who each drank 150 mg of Jiaogulan and 30 mg of Oolong tea per day (the treatment group) lived significantly longer ( P <0.05) than those who drank water only (the control group); there was a delay of 7~8 days for the occurrence of death in the treatment group; the treatment produced a significant effect of inhibition on the growth of tumour ( P <0.05~0.001) at the early and middle stages; and the apparent living quality of the treatment group was better than that of the control group. However, an administration of Jiaogulan at 30 mg per day showed no such effect. In addition, Oolong tea had a strong effect of inhibition on the proliferation of a variety of tumour cell lines in culture bottles, with the average rate of inhibition being>86.2% and the strongest effect resulting from a concentration of 200 μg/mL.