摘要
在 1 7-( 3 -吡唑基 )和 1 7-( 5 -异噁唑基 )雄甾 -4 ,1 6-二烯 -3 -酮的吡唑基的 5 -位和异唑基的 3 -位引入取代基 ,设计并合成了 1 1个 1 7-(取代的吡唑基、异唑基 )雄烯衍生物 ,化合物的结构经 1H NMR,IR。
Pyrazolyl) and 17 (5 isoxazolyl)androsta 4,16 dien 3 one have been found to be potent inhibitors for human testicular microsomal 17α hydroxylase/C 17,20 layse, which showed potential usage in the treatment of benign prostatic hypertrophy(BPH) and prostatic cancer. In order to further investigate their structure activity relationship, some substituents were introduced at the 5 position of pyrazole and 3 position of isoxazole, and eleven derivatives were obtained. The structures of the compounds were confirmed by IR, 1H NMR, elemental analysis or MS measurements. Their pharmacological activities are under investigation.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第6期931-935,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金! (批准号 :3 9670 85 5 )
美国 N IH基金! (批准号 :CA2 7440 )资助