摘要
This paper investigated a rapid one pot synthesis method of some substituted（9 carbazoly） carboxylic acids（3a3m）. The reaction was carried out by mixing of the 9H carbazoles derivatives with bromo esters and potassium hydroxide using DMF as solvent under microwave irradiation without catalyst. The optimized experiment conditions were 48 min irradiation time and 375 W microwave power. The required range of molar ratio of KOH to substituted carbazole was 35. The biological activities of some compounds have been tested. They have medium to weak antimicrobial activities.
This paper investigated a rapid one pot synthesis method of some substituted(9 carbazoly) carboxylic acids(3a_3m). The reaction was carried out by mixing of the 9H carbazoles derivatives with bromo esters and potassium hydroxide using DMF as solvent under microwave irradiation without catalyst. The optimized experiment conditions were 4_8 min irradiation time and 375 W microwave power. The required range of molar ratio of KOH to substituted carbazole was 3_5. The biological activities of some compounds have been tested. They have medium to weak antimicrobial activities.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第6期955-957,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金! (批准号 :2 9870 5 3 3 )资助
