摘要
Nanocrystalline TiO 2 particles film has been considered as an eminent matrix for the immobilization of biomolecules due to its high biocompatiability, high protein loading and special binding ability. The direct electron transfer process of hemoglobin was achieved at nanosized TiO 2 film electrode, in which a well defined redox peak of hemoglobin could be observed. However, this peak decreased with the presence of NO, indicating the electrochemical activity of hemoglobin was inhibited by the interation between hemoglobin and NO. While the further evidence revealed that such activity could be recovered after releasing NO from hemoglobin with electrochemical oxidation method.
Nanocrystalline TiO 2 particles film has been considered as an eminent matrix for the immobilization of biomolecules due to its high biocompatiability, high protein loading and special binding ability. The direct electron transfer process of hemoglobin was achieved at nanosized TiO 2 film electrode, in which a well defined redox peak of hemoglobin could be observed. However, this peak decreased with the presence of NO, indicating the electrochemical activity of hemoglobin was inhibited by the interation between hemoglobin and NO. While the further evidence revealed that such activity could be recovered after releasing NO from hemoglobin with electrochemical oxidation method.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第8期1373-1375,共3页
Chemical Journal of Chinese Universities
基金
国家九七三项目 (批准号 :G19990 5 440 4)
国家自然科学基金重点项目 (批准号 :2 0 0 75 0 15 )
