1,3,5-三甲氧基苯的合成

Synthesis of 1,3,5-Trimethoxybenzene

以 1 ,3,5-三溴苯为原料 ,二甲基甲酰胺 (DMF)和甲醇为溶剂 ,Cu Cl为催化剂 ,通过甲氧基化反应高收率地制备有机中间体 ,1 ,3,5-三甲氧基苯 ,收率可达 92 .3%。反应的适宜条件为 :甲醇钠 /1 ,3,5-三溴苯摩尔比为 6,DMF/甲醇的体积比为 2 .5,反应时间

The organic intermediate 1,3,5 trimethoxybenzene was prepared from 1,3,5 tribromobenzene in yield as high as 92.3%. The methoxylation reaction was carried out with dimethylformamide (DMF) and methanol as solvent, sodium methoxide as methoxylation agent and cuprous chloride as catalyst. The reaction conditions were: molar ratio of sodium methoxide/1,3,5 tribromobenzene was 6, volume ratio of DMF/methanol was 2.5, reaction time was 6 h.