包结物晶析法分离小茴香挥发油中茴香醚

Isolation of Anisole from Volatile Oil of Foemiculum Vulgare Mill by Crystalline Inclusion Method

用 GC-MS方法测定了小茴香挥发油的全组分 ,以 1 ,1 ,6,6-四苯基 -2 ,4 -己二炔 -1 ,6-二醇作为主体分子 ,选择性地将小茴香挥发油中的茴香醚作为客体 ,与之形成超分子包结物晶体 .采用 IR,粉末 XRD,1H NMR确定了包结物的形成及其主客体分子摩尔比为 2∶ 1 ,利用 Kugelrohr真空蒸馏技术将茴香醚从包结物晶体中分离出来 .用 IR,1H NMR,MS等方法 ,确定了被分离出化学组分的结构为反式茴香醚 .用 GC方法测定了选择分离挥发油化学组分 ,实验结果表明 ,该方法分离挥发油化学组分选择性高 ,速度快 。

The chemical components of volatile oil from Foemiculum Vulgare Mill were determined by GC-MS, amomg them 82.65% were anisole. A selective isolation of anisole from the volatile oil from mentioned seed has been carried out by an inclusion method. 1,1,6,6-Tetraphenyl-hexa-2,4-diyne-1,6-diol(abbrv. DD) was used as a host molecule with anisole being as a guest molecule. The structure of the inclusion complex was characterized by IR, XRD, ~1H NMR techniques and the host-guest molar ratio in complex was found to be 3∶1. The anisole was isolated from inclusion complex by using Kugelrohr vacuum distillation technique and the isolated compound was characterized to be trans-anisole.