摘要
Molecularly imprinted polymer(MIP) stationary phases against caffeine and against theophylline were prepared. Separation abilities of the phases were investigated by HPLC. The results showed that the theophylline based MIP stationary phase is highly selective to theophylline, and base lined separation of caffeine and theophylline was achieved. However, the caffeine based MIP stationary phase did not possess specific selectivity to the template molecule, caffeine. MIP with specific selectivity to template molecule can only be prepared when interactions between template and monomer go together.
Molecularly imprinted polymer(MIP) stationary phases against caffeine and against theophylline were prepared. Separation abilities of the phases were investigated by HPLC. The results showed that the theophylline based MIP stationary phase is highly selective to theophylline, and base lined separation of caffeine and theophylline was achieved. However, the caffeine based MIP stationary phase did not possess specific selectivity to the template molecule, caffeine. MIP with specific selectivity to template molecule can only be prepared when interactions between template and monomer go together.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第7期1122-1124,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 0 0 75 0 31)
关键词
高效液相色谱
分子烙印聚合物
咖啡因
茶碱
固定相
分离
High performance liquid chromatography
Molecular imprinted polymer
Caffeine
Theophylline
